Failure of combination therapy with daptomycin and synergistic ceftriaxone for enterococcal endocarditis.
نویسندگان
چکیده
Department of Pharmacy, Island Health, 1952 Bay St, Victoria, BC V8R 1J8, Canada; Department of Laboratory Medicine, Medical Microbiology Division, Island Health, 1952 Bay St, Victoria, BC V8R 1J8, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, G227–2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada; Department of Infectious Diseases, Island Health, 1952 Bay St, Victoria, BC V8R 1J8, Canada
منابع مشابه
Efficacy of daptomycin in the treatment of enterococcal endocarditis: a 5 year comparison with conventional therapy.
OBJECTIVES Enterococcus spp. account for 10% of infective endocarditis (IE). Although daptomycin is a bactericidal drug with in vitro activity against Enterococcus, there is little experience of its use in IE. We analysed the effectiveness of daptomycin in the treatment of enterococcal IE (EIE). METHODS This was a retrospective descriptive study comparing the efficacy of daptomycin versus amp...
متن کاملListeria monocytogenes endocarditis: case report, review of the literature, and laboratory evaluation of potential novel antibiotic synergies.
Endocarditis is a rare but serious manifestation of Listeria monocytogenes (LM). However, the optimal treatment strategy for LM endocarditis has yet to be established. Current antibiotic strategies for listeriosis include penicillin G or ampicillin (AMP) monotherapy, or AMP + gentamicin combination therapy which is often favored for endocarditis. The primary objective of our investigation was t...
متن کاملEvaluation of the novel combination of daptomycin plus ceftriaxone against vancomycin-resistant enterococci in an in vitro pharmacokinetic/pharmacodynamic simulated endocardial vegetation model.
OBJECTIVES Daptomycin has demonstrated synergy with β-lactams against Enterococcus faecium and this combination has been used successfully to treat infections refractory to daptomycin. We investigated daptomycin alone and combined with ceftriaxone against vancomycin-resistant enterococci (VRE) in an in vitro pharmacokinetic/pharmacodynamic simulated endocardial vegetation (SEV) model. METHODS...
متن کاملE. faecalis vancomycin-sensitive enterococcal bacteremia unresponsive to a vancomycin tolerant strain successfully treated with high-dose daptomycin.
Enterococci are part of the normal flora of the gastrointestinal tract. Intra-abdominal and genitourinary enterococcal infections may be complicated by enterococcal bacteremia. Most strains of enterococci fecal flora in antibiotic-naive patients are E. faecalis. Because nearly all E. faecalis strains are sensitive to vancomycin, E. faecalis is synonymous with vancomycin-sensitive enterococci (V...
متن کاملMitral valve endocarditis with high level aminoglycoside resistant Enterococcus faecalis in breast cancer patient
Introduction: Enterococci represent the third most common cause of infective endocarditis, after streptococcus and Staphylococcus aureus, and are responsible for 5–20% of all cases of endocarditis. We present a rare case of native valve Enterococcus faecalis (E. faecalis) endocarditis of mitral valve in a breast cancer patient. Case Report: A 56yearold breast cancer patient presented with com...
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ورودعنوان ژورنال:
- The Journal of antimicrobial chemotherapy
دوره 70 2 شماره
صفحات -
تاریخ انتشار 2015